This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects. What is the most important information I should know about Losartan Potassium and Hydrochlorothiazide tablets? These could cause you to have low blood pressure. Thiazides cross the placental barrier and appear in cord blood. There is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults. costco pharmacy condyline price condyline
Renal and urinary disorders: Glycosuria, renal dysfunction, interstitial nephritis, renal failure. Nicergoline: May enhance the hypotensive effect of Blood Pressure Lowering Agents. What Is Losartan and How Does It Work? discount asacol kit
There are no dosage adjustments provided in the manufacturer's labeling. Lormetazepam: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Documentation of allergenic cross-reactivity for angiotensin receptor blockers is limited.
Instruct patient to lie or sit down if they experience dizziness or light-headedness when standing. Enzalutamide: May decrease the serum concentration of CYP2C9 Substrates. Management: Concurrent use of enzalutamide with CYP2C9 substrates that have a narrow therapeutic index should be avoided. Use of enzalutamide and any other CYP2C9 substrate should be performed with caution and close monitoring. If combined, monitor potassium, creatinine, and blood pressure closely. Losartan Potassium and Hydrochlorothiazide tablets can cause harm or death to an unborn baby. periactin
The mean age was 53 years. The NTP, however, found equivocal evidence for hepatocarcinogenicity in male mice. GFR is dependent on efferent arteriolar vasoconstriction by angiotensin II; deterioration may result in oliguria, acute renal failure, and progressive azotemia. Mitotane: May decrease the serum concentration of CYP3A4 Substrates. Management: Doses of CYP3A4 substrates may need to be adjusted substantially when used in patients being treated with mitotane. Symptomatic hypotension may occur after initiation of losartan in patients who are volume depleted eg, those treated with diuretics. Correct these conditions prior to administration of losartan or use a lower starting dose. AR antagonists, and the patient should be hemodynamically stable. Ideally, patients at risk for excessive hypotension should initiate AR antagonist therapy under close medical supervision, preferably with a lower dose, and followed closely for the first 2 weeks of treatment and whenever the dosage of AR antagonist or diuretic is increased. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. Prostacyclin Analogues: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Thiazides cross the placental barrier and appear in cord blood. At least 61 percent of the oral dose is eliminated unchanged within 24 hours. Hydrochlorothiazide crosses the placental but not the blood-brain barrier and is excreted in breast milk. In a controlled clinical study for the reduction in the combined risk of cardiovascular death, stroke and myocardial infarction in hypertensive patients with left ventricular hypertrophy, 2857 patients 62% were 65 years and over, while 808 patients 18% were 75 years and over. In an effort to control blood pressure in this study, patients were coadministered losartan and hydrochlorothiazide 74% of the total time they were on study drug. No overall differences in effectiveness were observed between these patients and younger patients. Amphetamines: May diminish the antihypertensive effect of Antihypertensive Agents.
Initiation of Losartan Potassium and Hydrochlorothiazide is not recommended for patients with hepatic impairment because the appropriate starting dose of losartan, 25 mg, is not available. CYP2C9 Substrates: CYP2C9 Inhibitors Moderate may decrease the metabolism of CYP2C9 Substrates. Obinutuzumab: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Management: Consider temporarily withholding blood pressure lowering medications beginning 12 hours prior to obinutuzumab infusion and continuing until 1 hour after the end of the infusion. Chest pain 12%; diabetic vascular disease, influenza-like symptoms 10%; infection 5%; diabetic neuropathy, fever, trauma 4%. Do not use a household spoon because you may not get the correct dose. Because AGTR1 is involved in the constriction of vessels, its activity is blocked by a class of drugs called angiotensin receptor blockers, which include losartan, the drug tested in this study. Losartan Potassium and Hydrochlorothiazide tablets are not usually the first medicine used to treat high blood pressure. Yohimbine: May diminish the antihypertensive effect of Antihypertensive Agents. Brimonidine Topical: May enhance the hypotensive effect of Blood Pressure Lowering Agents. These studies demonstrate that the incidence of cough associated with losartan therapy, in a population that all had cough associated with ACE inhibitor therapy, is similar to that associated with hydrochlorothiazide or placebo therapy. Persistent dry cough has been associated with ACE-inhibitor use and in practice can be a cause of discontinuation of ACE-inhibitor therapy. Two prospective, parallel-group, double-blind, randomized, controlled trials were conducted to assess the effects of losartan on the incidence of cough in hypertensive patients who had experienced cough while receiving ACE-inhibitor therapy. In efforts to control blood pressure, the patients in both arms of the LIFE study were coadministered hydrochlorothiazide the majority of time they were on study drug 73. High Blood Pressure hypertension. Blood pressure is the force in your blood vessels when your heart beats and when your heart rests. You have high blood pressure when the force is too much. The losartan ingredient in Losartan Potassium and Hydrochlorothiazide tablets can help your blood vessels relax so your blood pressure is lower. The hydrochlorothiazide ingredient in Losartan Potassium and Hydrochlorothiazide tablets work by making your kidneys pass more water and salt. bupropion
Fluconazole: May decrease the serum concentration of Losartan. Specifically, fluconazole may decrease the serum concentration of E3174, the more potent active metabolite of losartan. In this study, renal clearance was reduced by 55 to 85% for both losartan and its active metabolite in patients with mild or moderate renal insufficiency. Neither losartan nor its active metabolite can be removed by hemodialysis. Bosentan: May decrease the serum concentration of CYP3A4 Substrates. Who should not take Losartan Potassium and Hydrochlorothiazide tablets? The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. CYP2C8 Substrates: CYP2C8 Inhibitors Moderate may decrease the metabolism of CYP2C8 Substrates. In patients who experience a decline in renal function, discontinuation of AR antagonist therapy is usually not required provided there is symptomatic improvement of the heart failure and renal deterioration is well-tolerated. Transient hypotension is also not a contraindication to further treatment with AR antagonists, since therapy can usually be reinstated without difficulty after blood pressure stabilizes. Continued How Is Marfan Syndrome Diagnosed? Anaphylactic reactions, angioedema including swelling of the larynx and glottis, swelling of the face, lips, pharynx, and tongue vasculitis including Henoch-Schönlein purpura postmarketing. Gastrointestinal disorders: Dyspepsia, abdominal pain, gastric irritation, cramping, diarrhea, constipation, nausea, vomiting, pancreatitis, sialoadenitis. But if there were a study in which losartan were given only to women with breast cancers linked to overexpression of AGTR1, it would be much easier to detect an effect. Before such a trial can be set up, however, scientists must first develop a way to easily detect AGTR1 overexpression. Marfan syndrome can rupture the inner layers of the aorta, causing dissection that leads to bleeding in the wall of the vessel. Aortic dissection can be deadly. Surgery may be required to replace the affected part of the aorta. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. When pregnancy is detected, discontinue losartan as soon as possible. Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than 1 drug to achieve blood pressure goals. CloZAPine: CYP1A2 Inhibitors Weak may increase the serum concentration of CloZAPine.
Hypotension-Associated Agents: Blood Pressure Lowering Agents may enhance the hypotensive effect of Hypotension-Associated Agents. Methylphenidate: May diminish the antihypertensive effect of Antihypertensive Agents. Drospirenone: Angiotensin II Receptor Blockers may enhance the hyperkalemic effect of Drospirenone. Plasma losartan concentrations are twice as high in hypertensive women as hypertensive men, but plasma concentrations of active metabolite are similar. No dosage adjustment is necessary. Shake suspension well before measuring and administering prescribed dose. Use dosing syringe, dosing spoon, or dosing cup to measure and administer dose. Return suspension to refrigerator immediately after measuring dose. Emotional considerations. Learning you have Marfan syndrome may cause you to feel angry, frightened or sad. You may need to make changes in your lifestyle and adjust to having careful medical follow-up the rest of your life. You may have financial concerns. You also need to consider the risk to your future children. The National Marfan Foundation can provide support. The goal of surgery for Marfan syndrome is to prevent aortic dissection or rupture and to treat problems affecting the heart's valves, which control the flow of blood in and out of the heart and between the heart's chambers. Make dose adjustments as needed unless the patient is volume depleted. Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Losartan Potassium and Hydrochlorothiazide as soon as possible. Surgical patients: In patients on chronic angiotensin receptor blocker ARB therapy, intraoperative hypotension may occur with induction and maintenance of general anesthesia; however, discontinuation of therapy prior to surgery is controversial. If continued preoperatively, avoidance of hypotensive agents during surgery is prudent Hillis, 2011. Keep Losartan Potassium and Hydrochlorothiazide tablets and all medicines out of the reach of children. CYP3A4 Inducers Strong: May increase the metabolism of CYP3A4 Substrates. Management: Consider an alternative for one of the interacting drugs. Some combinations may be specifically contraindicated. Consult appropriate manufacturer labeling. Drugs that act on the renin-angiotensin system can cause injury and death to the developing fetus. Discontinue as soon as possible once pregnancy is detected. online norethisterone buy
Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure JNC. Losartan Potassium and Hydrochlorothiazide tablets can be taken with or without food. Cannabis: CYP2C9 Inhibitors Moderate may increase the serum concentration of Cannabis. More specifically, tetrahydrocannabinol serum concentrations may be increased. The antihypertensive effects of the drug may be enhanced in the postsympathectomy patient. Losartan Potassium and Hydrochlorothiazide can pass into your milk and may harm your baby. You and your doctor should decide if you will take Losartan Potassium and Hydrochlorothiazide tablets or breastfeed. You should not do both. Refer to adult dosing. Nonsteroidal Anti-Inflammatory Agents. Specifically, the combination may result in a significant decrease in renal function. Nonsteroidal Anti-Inflammatory Agents may diminish the therapeutic effect of Angiotensin II Receptor Blockers. The combination of these two agents may also significantly decrease glomerular filtration and renal function. Respiratory, thoracic and mediastinal disorders: Nasal congestion, pharyngitis, sinus disorder, respiratory distress including pneumonitis and pulmonary edema. Marfan syndrome requires a treatment plan that is individualized to the patient's needs. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Losartan belongs to a class of drugs called ARBs. It works by relaxing blood vessels so that blood can flow more easily. Use caution in treating patients whose renal function may depend on the renin-angiotension-aldosterone system eg, patients with severe CHF. Blocks vasoconstriction and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the angiotensin II receptor AT 1 receptor in vascular smooth muscle and the adrenal gland. Increases in serum lithium concentrations and lithium toxicity have been reported with concomitant use of angiotensin II receptor antagonists or thiazide diuretics. Monitor lithium levels in patients receiving Losartan Potassium and Hydrochlorothiazide and lithium. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Losartan Potassium and Hydrochlorothiazide contains hydrochlorothiazide which can cause hypokalemia, hyponatremia and hypomagnesemia. Hypomagnesemia can result in hypokalemia which may be difficult to treat despite potassium repletion. Losartan Potassium and Hydrochlorothiazide also contains losartan which can cause hyperkalemia. Others may need or surgery.
Ora-Plus and Ora-Sweet SF; add to tablet and water mixture in the bottle and shake for 1 minute. Label "shake well" and "refrigerate". Return promptly to refrigerator after each use. Stable for 4 weeks when stored in amber polyethylene terephthalate prescription bottles and refrigerated Cozaar prescribing information, 2015. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Limited data are available in regard to overdosage in humans. The most likely manifestation of overdosage would be hypotension and tachycardia; bradycardia could occur from parasympathetic vagal stimulation. If symptomatic hypotension should occur, supportive treatment should be instituted. Inform patient that drug controls, but does not cure, hypertension and to continue taking drug as prescribed even when BP is not elevated. When used in pregnancy during the second and third trimesters, drugs that act directly on the renin-angiotensin system can cause injury and even death to the developing fetus. When pregnancy is detected, discontinue therapy as soon as possible. Nitroprusside: Blood Pressure Lowering Agents may enhance the hypotensive effect of Nitroprusside. Keep Losartan Potassium and Hydrochlorothiazide tablets in a tightly closed container, and keep Losartan Potassium and Hydrochlorothiazide tablets out of the light. Within 1 to 2 weeks after initiation, reassess blood pressure including postural blood pressure changes renal function, and serum potassium; follow closely after dose changes. Know the medicines you take. Keep a list of your medicines and show it to your doctor and pharmacist when you get a new medicine. Reduction in the Risk of Stroke: The LIFE study was a multinational, double-blind study comparing losartan and atenolol in 9193 hypertensive patients with ECG-documented left ventricular hypertrophy. Patients with myocardial infarction or stroke within six months prior to randomization were excluded. Hypoglycemia 14%; hyperkalemia 7%; weight gain 4%; hyponatremia postmarketing. Instruct patient to immediately discontinue drug and notify health care provider if any of the following occur: swelling of the face, lips, eyelids, or tongue, difficulty breathing, or difficulty swallowing. What Are Side Effects Associated with Using Losartan? buy omeprazole buller
Losartan Potassium and Hydrochlorothiazide. Monitor renal function periodically in these patients. Aurobindo Pharma USA, Inc. CycloSPORINE Systemic: Angiotensin II Receptor Blockers may enhance the hyperkalemic effect of CycloSPORINE Systemic. Hypotension: Symptomatic hypotension may occur upon initiation in patients who are salt or volume depleted eg, those treated with high-dose diuretics; correct volume depletion prior to administration. This transient hypotensive response is not a contraindication to further treatment with losartan. USP and 25 mg of hydrochlorothiazide USP. Inactive ingredients are colloidal silicon dioxide, hydroxypropyl cellulose, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, pregelatinisedstarchmaize and titanium dioxide. Following oral administration, the AUC for hydrochlorothiazide is increased by 70 and 700% for patients with mild and moderate renal insufficiency, respectively. In this study, renal clearance of hydrochlorothiazide decreased by 45 and 85% in patients with mild and moderate renal impairment, respectively. If you get pregnant while taking Losartan Potassium and Hydrochlorothiazide tablets, tell your doctor right away. Molsidomine: May enhance the hypotensive effect of Blood Pressure Lowering Agents.
Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? Neonates with a history of in utero exposure to Losartan Potassium and Hydrochlorothiazide: If oliguria or hypotension occurs, direct attention toward support of blood pressure and renal perfusion. How should I store Losartan Potassium and Hydrochlorothiazide tablets? Distribution: The volume of distribution of losartan and the active metabolite is about 34 liters and 12 liters, respectively. Medicines are sometimes prescribed for conditions that are not mentioned in patient information leaflets. Do not use Losartan Potassium and Hydrochlorothiazide tablets for a condition for which it was not prescribed. Do not give Losartan Potassium and Hydrochlorothiazide tablets to other people, even if they have the same symptoms that you have. Advise patient to monitor and record BP and pulse at home and to inform health care provider if abnormal measurements are noted. Advise patient to take record of BP and pulse to each follow-up visit. Patients receiving the combination of losartan and lisinopril did not obtain any additional benefit compared to monotherapy for the combined endpoint of decline in GFR, end-stage renal disease, or death, but experienced an increased incidence of hyperkalemia and acute kidney injury compared with the monotherapy group. Hydrochlorothiazide was not genotoxic in vitro in the Ames mutagenicity assay of Salmonella typhimurium strains TA 98, TA 100, TA 1535, TA 1537, and TA 1538 and in the Chinese Hamster Ovary CHO test for chromosomal aberrations, or in vivo in assays using mouse germinal cell chromosomes, Chinese hamster bone marrow chromosomes, and the Drosophila sex-linked recessive lethal trait gene. Losartan Potassium and Hydrochlorothiazide is available for oral administration in three tablet combinations of losartan and hydrochlorothiazide. Chronic kidney disease CKD and hypertension: Regardless of race or diabetes status, the use of an ACE inhibitor ACEI or angiotensin receptor blocker ARB as initial therapy is recommended to improve kidney outcomes. In the general nonblack population without CKD including those with diabetes, initial antihypertensive treatment should consist of a thiazide-type diuretic, calcium channel blocker, ACEI, or ARB. In the general black population without CKD including those with diabetes, initial antihypertensive treatment should consist of a thiazide-type diuretic or a calcium channel blocker instead of an ACEI or ARB. Antihepaciviral Combination Products: May increase the serum concentration of Losartan. Management: Per antihepaciviral combination product US prescribing information, consider decreasing the losartan dose and monitoring for evidence of hypotension and worsening renal function if these agents are used in combination. Musculoskeletal and connective tissue disorders: Muscle cramps, muscle spasm, myalgia, arthralgia. Amodiaquine: CYP2C8 Inhibitors may increase the serum concentration of Amodiaquine. They may harm them. Hydrochlorothiazide USP is a white or practically white, practically odorless, crystalline powder with a molecular weight of 297. lamivudine
Blood and the lymphatic system disorders: Anemia, aplastic anemia, hemolytic anemia, leukopenia, agranulocytosis. F. Protect from light. Losartan is used to treat high blood pressure hypertension and to help protect the kidneys from damage due to diabetes. It is also used to lower the risk of strokes in patients with high blood pressure and an enlarged heart. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Losartan belongs to a class of drugs called angiotensin receptor blockers ARBs. It works by relaxing blood vessels so that blood can flow more easily. Absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins. Single doses of either cholestyramine or colestipol resins bind the hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by up to 85 and 43 percent, respectively. Stagger the dosage of hydrochlorothiazide and the resin such that hydrochlorothiazide is administered at least 4 hours before or 4 to 6 hours after the administration of the resin. Hypersensitivity reactions to hydrochlorothiazide may occur in patients with or without a history of allergy or bronchial asthma, but are more likely in patients with such a history. The effect of losartan is substantially present within one week but in some studies the maximal effect occurred in 3 to 6 weeks. In long-term follow-up studies without placebo control the effect of losartan appeared to be maintained for up to a year. There is no apparent rebound effect after abrupt withdrawal of losartan. There was essentially no change in average heart rate in losartan-treated patients in controlled trials. OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. Phosphodiesterase 5 Inhibitors: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Those with dilation of the aorta will be asked to avoid high intensity team sports, contact sports, and isometric exercises such as . Ask your cardiologist about activity guidelines for you. How Does Marfan Sydrome Affect Lifestyle Choices? Ora-Plus and Ora-Sweet SF. Combine 10 mL of purified water and ten losartan 50 mg tablets in a 240 mL amber polyethylene terephthalate bottle. Shake well for at least 2 minutes. Allow concentrate to stand for 1 hour, then shake for 1 minute.
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Back pain 12%; muscular weakness 7%; knee pain, leg pain 5%; muscle cramp 1%; rhabdomyolysis postmarketing. LVH. Losartan Potassium and Hydrochlorothiazide tablets may not help Black patients with this problem. Losartan plasma levels may be reduced, decreasing the antihypertensive effects. In patients who are hypersensitive to any component of this product. how to purchase eskazole otc eskazole
If surgery is needed, you should consult with a surgeon who is experienced in surgery for Marfan syndrome. People who have surgery for Marfan syndrome still require life-long follow-up care to prevent future complications associated with the disease. Ceritinib: May increase the serum concentration of CYP2C9 Substrates. ACE Inhibitors. Angiotensin II Receptor Blockers may increase the serum concentration of ACE Inhibitors. Management: In US labeling, use of telmisartan and ramipril is not recommended. It is not clear if any other combination of an ACE inhibitor and an ARB would be any safer. Consider alternatives to the combination when possible.
Side Effects List Losartan POTASSIUM side effects by likelihood and severity. The double-blind treatment period lasted up to 8 weeks. The incidence of cough is shown in Table 1 below. The AUC of active metabolite following oral losartan was not affected by erythromycin, an inhibitor of P450 3A4, but the AUC of losartan was increased by 30%. There was no difference in response for men and women or in patients over or under 65 years of age. adol.info sotalol
At the end of study or at the last visit before a primary endpoint, 77% of the group treated with losartan and 73% of the group treated with atenolol were still taking study medication. After oral administration of hydrochlorothiazide, diuresis begins within 2 hours, peaks in about 4 hours, and lasts about 6 to 12 hours. Black patients: When used to reduce the risk of stroke in patients with HTN and LVH, may not be effective in the black population. The decision to perform surgery is based on the size of the aorta, expected normal size of the aorta, rate of aortic growth, age, height, gender, and family history of aortic dissection. Surgery involves replacing the dilated portion of the aorta with a graft, a piece of man-made material that is inserted to replace the damaged or weak area of the blood vessel.